Geometric mean is sometimes used in quantization because it corrects for:

The geometric mean is employed in quantification, particularly in nuclear medicine, to address the challenges posed by attenuation and organ depth. When imaging, particularly in structures that may be obscured or altered due to surrounding tissues, the geometric mean provides a more accurate measure of radioactivity. This technique averages the counts from two or more detectors placed around the organ of interest, helping to mitigate the effects of attenuation that can skew results.

Attenuation occurs when gamma rays emitted from radioisotopes within the body are partially absorbed or scattered by overlying or surrounding tissues. This can lead to an underestimation of the true activity within a region of interest. The geometric mean thus serves to enhance the quantification of radionuclide distribution by taking into account the relative contributions of counts from different angles, effectively compensating for organ depth differences and the varying absorption characteristics of different tissues.

By employing this statistical measure, the effects of overlying or adjacent structures are minimized, allowing for a more reliable assessment of organ function and radiopharmaceutical uptake. This approach is especially beneficial in clinical situations, such as when evaluating tumors or other lesions, where accurate representation of activity is critical for diagnosis and treatment planning.