Significantly increased serum bilirubin levels are likely to visualize which organ on hepatobiliary images?

The correct answer is the liver. Significantly increased serum bilirubin levels primarily indicate liver dysfunction. In conditions such as hepatitis, cirrhosis, or obstruction of the bile ducts, the liver's ability to process and excrete bilirubin is impaired, leading to elevated levels in the bloodstream.

On hepatobiliary imaging, such as HIDA scans, the liver becomes more prominent due to its role in producing and processing bilirubin. The images may reveal alterations in liver appearance or function depending on the underlying cause of the elevated bilirubin. Increased bilirubin can result in the visualization of liver dysfunction, even if the organ itself is not directly imaged in the same manner as other structures like the gallbladder or kidneys, which would not typically be influenced by serum bilirubin levels in this context.

In the case of the gallbladder, kidneys, and pancreas—these organs may not show any specific changes related to increased bilirubin levels. The primary impact of bilirubin levels is on the liver and its functionality in the hepatobiliary system, making it the most relevant organ in this scenario.