What is the maximum percentage difference acceptable for most regulatory agencies for dose calibrator QC checks?

Regulatory agencies typically allow a maximum percentage difference of +/- 10% for dose calibrator quality control (QC) checks. This standard ensures that the measurements of radioactive doses are accurately represented and safe for patient use. Maintaining this level of accuracy is critical since even minor discrepancies can lead to significant variations in patient treatment and diagnostics. A tolerance of 10% strikes a balance—ensuring sufficient precision in radioactivity measurements without making the QC process overly stringent or impractical to execute regularly.

The other percentages exceed what is commonly accepted, which could lead to higher risks of incorrect dosing or inaccurate diagnostic information. Thus, the choice of +/- 10% is seen as a widely accepted standard across various institutions and regulatory bodies in the field of nuclear medicine.