Which image finding is most consistent with chromatography results of a 99mTc oxidronate sample demonstrating 65% radiochemical purity?

In the context of 99mTc oxidronate (also known as 99mTc-MDP) used in bone imaging, the interpretation of radiochemical purity is essential for understanding the expected distribution of the radiopharmaceutical in the body. A sample demonstrating 65% radiochemical purity indicates that a significant portion of the radiolabeled compound is present in forms that may not be biologically relevant, meaning there could be substantial free pertechnetate or other radiochemical impurities.

When considering the findings that would correlate with a lower radiochemical purity, the uptake in organs such as the stomach and thyroid is indicative. These organs are known to uptake free pertechnetate due to their physiological processes—namely, the thyroid captures pertechnetate for synthesis of thyroid hormones, and the stomach can absorb pertechnetate where mucosal uptake occurs.

In contrast, well-defined bone uptake is typically seen with a highly pure sample where the radiotracer specifically binds to bone tissues, indicating proper functioning of the imaging agent without significant impurities. In this case, the expected radiological distribution would show clear localization within the bones rather than the stomach or thyroid.

The other scenarios like heart and gastrointestinal tract uptake also would not correspond to the indications of