Which method can help mitigate the risk of allergic reactions during imaging procedures?

Administering diphenhydramine helps mitigate the risk of allergic reactions during imaging procedures, particularly those involving contrast agents. Diphenhydramine is an antihistamine that can alleviate the symptoms of allergic reactions by blocking the action of histamine, a substance released during allergic responses. This medication is often premedicated in patients with a history of allergic reactions to contrast media to help prevent or reduce the severity of these reactions.

While other methods mentioned might have their merits in specific situations, they do not directly address the prevention of allergic reactions. Increasing contrast volume could potentially increase the risk of allergic reactions, as a larger dose may provoke a more severe response. Using sedation is primarily aimed at patient comfort and anxiety reduction rather than mitigating allergic risks. Reducing exposure time relates more to radiation protection than to managing allergic reactions.