Which method is used to determine the concentration of 99Mo in a 99mTc eluate?

The correct answer involves measuring the eluate of 99mTc for 99Mo while utilizing a lead shield to ensure accurate readings. Specifically, when determining the concentration of 99Mo in a 99mTc eluate, the lead shield serves an important function by absorbing the high-energy photons that are emitted by 99Mo. This reduces the interference that these photons could create during the measurement, allowing for more precise determination of the 99Mo activity.

Setting the dose calibrator specifically to assay for 99Mo ensures that it is tuned to detect the appropriate energy levels associated with the 99Mo without being influenced by the emissions of the 99mTc. This method is crucial since 99mTc is the primary radiopharmaceutical derived from the decay of 99Mo, and distinguishing between the two isotopes is necessary for ensuring patient safety and treatment effectiveness.

In summary, using a lead shield combined with a dose calibrator adjusted for 99Mo allows for accurate assessment of its concentration in the eluate, which is vital when evaluating potential contamination and ensuring proper dosing in nuclear medicine applications.