Which radiopharmaceutical can cross the intact blood-brain barrier?

The radiopharmaceutical capable of crossing the intact blood-brain barrier is 99mTc bicisate. This compound is specifically designed to have a favorable lipophilicity, which allows it to penetrate the fatty membranes that constitute the blood-brain barrier. This property makes it ideal for evaluating cerebral perfusion or abnormalities in brain function, particularly in studies involving neurological conditions.

In contrast, the other options do not have the ability to cross the blood-brain barrier effectively. For example, 99mTc pertechnetate is primarily utilized for thyroid imaging and does not penetrate the brain tissue due to its hydrophilic nature. Similarly, 99mTc glucepate and 99mTc pentetate are designed for renal and cardiac imaging, respectively, and lack the characteristics necessary to traverse the blood-brain barrier. Therefore, the selection of 99mTc bicisate is pivotal for applications targeting the central nervous system in nuclear medicine.