Which should not be administered with In-111 Pentetreotide?

In-111 Pentetreotide is a radiolabeled somatostatin analog used in nuclear medicine primarily for imaging neuroendocrine tumors and evaluating somatostatin receptor expression. When considering its administration, it is crucial to ensure that it does not interact adversely with other substances.

Total parenteral nutrition (TPN) mixes often contain a variety of components, including lipids, amino acids, and carbohydrates, which can complicate the absorption or distribution of radiopharmaceuticals like In-111 Pentetreotide. TPN mixes are designed to provide complete nutrition intravenously and could potentially alter the pharmacokinetics of In-111 Pentetreotide, leading to inaccurate imaging results or diminished binding efficacy to the somatostatin receptors that are being studied.

On the other hand, calcium infusion, saline solution, and antibiotics generally do not create significant interactions with In-111 Pentetreotide. Saline is often used to maintain hydration and provide a vehicle for administering other medications. Antibiotics may be used concurrently if there is an existing infection, and they typically do not interfere with the imaging capabilities of the radiotracer.

Thus, administering TPN mixes together with In-111 Pentetreotide is not advisable due to the risk of negatively